In This Issue of JoGG
In this second issue of the Journal of Genetic Genealogy (JoGG), completing Volume 1, we have three original articles, one of each of the types of articles that JoGG publishes, regular articles, review articles, and brief communications.
The article on the “Pitfalls of Determining
Haplogroup F*,” by
Ian Logan has written a review of the medical
implications of whole-genome mtDNA sequencing.
In contrast to the HVR1 and HVR2 results with which we’ve become
familiar, one should not order a full mtDNA sequence without understanding that
medically important information may come with the results. There is not only a privacy issue, but also
there are u
Dr. Logan’s estimates that 5-10% of people who have the full mtDNA sequence may have a “medically significant mutation,” which is a surprisingly high percentage. However, it should be remembered that most of the medically significant mutaions will not necessarily lead to actual expression of a disease, but only to increased susceptibility.
The brief communication for this month is another
small study organized by amateurs, but with important implications for the Y
phylogenetic tree. This article by
Ann Turner continues her regular column for JoGG entitled “’Satiable Curiosity,” designed to connect the needs and resources of the genealogy community with those of the professional geneticists. Her current column addresses “The Case of the Ubiquitous 16519C.” In this column she examines the reasons for this mutation showing up in so many mtDNA haplogroups. Is it simply because the CRS sequence has a rare polymorphism at this site, causing “differences from CRS” to occur almost everywheore, or have many different independent mutations occurred at this site?